Dr Gillespie claimed the seat with a 3.63 per cent swing for the Nationals taking 65.49 per cent of the projected two candidate preferred vote ahead of Labor candidate Phil Costa with 38.37 per cent of the electorate's support.

Of the 118,865 people enrolled to vote in Lyne, there were 81,545 formal votes and 7671 informal votes cast.

There were nine candidates contesting the seat.

The electorate of Lyne was named after Sir William Lyne who was named Premier of New South Wales 1899-1901.

Dr Gillespie was elected to the seat in 2013.

It was a successful day for the Nationals on the Mid North Coast with Patrick Conaghan, a newcomer to politics, claiming victory over independent Rob Oakeshott in the seat of Cowper.

Barnaby Joyce has retained the seat of New England. The incumbent Nationals MP had attracted more than 27,000 first preferences, or 53 per cent of the vote.

Mr Joyce, who is set for a third term as the local member, thanked his supporters and his volunteers.